The bank of the River Po starts in Casale Monferrato, a place that calls for a visit. Stop to learn more about the history of the Marquisate of Monferrato , climb the rolling hills covered in vineyards and wordl-famous wineries, try the unique cuisine of this part of the Piedmont Region. Here is where the Po becomes the Great River, widening in the boundless plain. Its meandres flow slowly among beaches of white pebbles and soft sand that is deposited by the river to create small islands along the banks, doomed to disappear the first time the river overflows. It is fed by the crystal, blue waters of the Ticino immediately after the city of Pavia, a beautiful phenomenon that can be watched from the bridge “della Becca”. The two rivers flow side by side for about 2 km and then start to slowly merge.

You can then abandon the bank of the river to visit Pavia, the ancient capital of the Longobards, and don't forget Lomello, a settlement of the late Middle Ages that gives its name to the Lomellina region. You should stop for a coffee in the town square in Vigevano and then visit the small villages on both sides of the river. In each you will find an old traditional tavern and a street named “Via Po” that leads to the landing spots on the river bank, where the traditional flat-bottomed boats are moored.

Cycle along the embankment between Pavia and Piacenza, where you will find the road signs of the Po Cycle Route Ciclovia del Po and of the Via Francigena . Immediately after Orio Litta you will find the medieval crossing Transitum Padi, where today's pilgrims wait on the jetty for a modern motorboat.

The City of Piacenza is not far, you just have to follow the embankment. Stop in Cavalli square to visit the beautiful Romanesque churches. The River flows under the bridges, with its deep meandres lapping the cut-off branches of the island of Pinedo, where you can proceed cautiously on small boats to explore shadowy, green nooks. Then continue to the biggest island on the river, Isola Serafini, cross the island and stop on its wide white beaches, incessantly created and then destroyed by the waters, to take a look at the River Adda at the end of its journey, when it meets the Great River.